中国农业科学院 作物科学研究所
Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China

 

Genetic model 1 used in simulations

 

1. Introduction

The first genome consisted of 6 chromosomes, each of 150 cM in length and with 16 evenly distributed markers. Ten predefined QTL similar to those in Zeng (1994) (represented by QZ1 to QZ10; Table 2) were assumed to contribute to the trait of interest. Three QTL were located on each of the first three chromosomes, and one QTL on the fourth chromosome. There was no QTL on chromosomes 5 and 6. The locations and genetic effects (additive and epistatic effects) of the ten simulated QTL are shown in Table 2. Under this QTL distribution, the theoretical additive and epistatic variances were both equal to 4.67, calculated using equations (8) and (9). Heritability in the broad sense for the trait of interest was set at 0.8. One hundred backcross populations each of 200 individuals were simulated.

For more details see Li H, Ye G, Wang J (2007) A modified algorithm for the improvement of composite interval mapping. Genetics 175:361-374.

 

2. Input file for Windows QTL IciMapping (Li2007.qtl)

 

3. 100 backcross populations for Windows QTL Cartographer (Li2007CIM)

 

4. 100 backcross populations for Empiricam Bayesian Model (Li2007BAYES)

 

5. 100 backcross populations for Windows QTL IciMapping (Li2007ICIM)

 

6. Results from ICIM